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Blood groups and Lewis Antigens

Histo-Blood groups antigens also called HBGs (A, B, H) and related antigens are complex carbohydrates present on the surface of red blood cells and mucosal epithelium of the respiratory, genitourinary and digestive tracks. They are also present as free oligosaccharides in biologic fluids such as saliva, intestinal content, milk (HMO) and blood.

  • Secretor phenotype (Se): ABH antigens are expressed along the oro-gastrointestinal mucosal of individuals of positive secretor status. Se individuals express the Secretor-fucosyl transferase FUT2 producing the H antigen.

  • Non secretor phenotype (Se0): Individuals of non secretor phenotype lack the secretor-transferase and make shorter Lewisa antigen (Lea)

  • Bombay phenotype: Individuals lack fucosylated ABH antigens on erythrocytes in circulation (rare phenotype) due to mutation of FUT1 allele.

Lewis Antigens

Lewis X tetraose-N-acetyl-propargyl

Lewis X tetraose-N-acetyl-propargyl
trait
GLY050-NPR

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Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ-NAc-propargyl
Lewis Antigens

Lewis X tetraose-Nacetyl-spacer1-NH2

Lewis X tetraose-Nacetyl-spacer1-NH2
trait
GLY050-Nac-sp1-NH2

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Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ-NAc-sp1-NH2
Lewis Antigens

LewisX (LeX) hexaose linked to BSA / Lacto-N-neoDiFucohexaose-BSA / LNnDFH-BSA

LewisX (LeX) hexaose linked to BSA / Lacto-N-neoDiFucohexaose-BSA / LNnDFH-BSA
trait
GLY051-BSA

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Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc
Lewis Antigens

Lewisb (Leb) tetraose

Lewis<sup>b</sup> (Le<sup>b</sup>) tetraose
trait
GLY045

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Fucα1-2Galβ1-3(Fucα1-4)GlcNAc
C26H45NO19
FW 675.63
[80081-06-7]
Lewis Antigens

Blood group B LewisY antigen pentaose type 2

Blood group B Lewis<sup>Y</sup> antigen pentaose type 2
trait
GLY038-5

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Galα1-3(Fucα1-2)Galβ1-4(Fucα1-3)GlcNAc
C32H55NO24
FW 837.77
Lewis Antigens

LewisX (LeX) tetraose

Lewis<sup>X</sup> (Le<sup>X</sup>) tetraose
trait
GLY050

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Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal
C26H45NO20
FW 691.62
Blood group A antigens

6GrA1-N-acetyl-spacer4-NH2

trait
GLY037-NAcsp4-NH2

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GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3
Galβ1-4Glcβ-N-Acetyl-Spacer4-NH2
Blood group A antigens

6GrA1-NAc-spacer2-NH2

trait
GLY037-1-NAcsp2-NH2

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GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3
Galβ1-4Glc-N-Acetyl-spacer2-NH2
Blood group H antigens (Blood group O)

Blood group H antigen tetraose type 2 - amine

trait
GLY032-2-NacSp1-NH2

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Fucα1-2Galβ1-4GlcNAcβ1-3Galβ-NAc-Spacer 1-NH2
Lewis Antigens

LewisX (LeX) hexaose / Lacto-N-neoDiFucohexaose / LNnDFH

Lewis<sup>X</sup> (Le<sup>X</sup>) hexaose / Lacto-N-neoDiFucohexaose / LNnDFH
trait
GLY051

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Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc
C38H65NO29
FW 999.90
Blood group H antigens (Blood group O)

Blood group H antigen triaose type5-NAc-spacer1-NH2

trait
GLY031-3-NAc-sp1-NH2

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Fucα1-2Galβ1-4Glcβ-NAc-spacer1-NH2
Blood group A antigens

Blood group A antigen tetraose type 5-NAc-spacer2-NH2

trait
GLY035-3-NAcSp2-NH2

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GalNAcα1-3(Fucα1-2)Galβ1-4Glc
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