Product code: LEC538
Sugar specificity: N-Acetylglucosamine (GlcNAc)
Additional specificity details: N-Acetylneuraminic acid (Neu5Ac) residues of glycoproteins and glycolipids
Structure: Dimeric lectin of 36 kDa
The WGA lectin agglutinates erythrocytes and most types of malignant cells. It agglutinates rabbit erythrocytes at < 0.1 μg/ml following trypsin treatment of the cells. Adding 300 mM N Acetyle-D-Glucosamine gives an inhibition with a titer that is at least 8-fold lower than the control. Wheat germ agglutinin inhibits the C5a receptor interaction, which has implications in studies of receptor micro-heterogeneity and ligand binding sites. WGA together with Con A is the lectin most widely used as an analytical and preparative agent when studying glycoproteins and cell surface proteins. The immobilized lectin can be used for affinity chromatography of cells and sub-cellular particles.
Synonyms:Weat germ agglutinin (WGA)
Laboratory reagent for research and development only. Not for human or animal use.