Glycans and Glycoconjugates expertise
BUILD YOUR GLYCAN
The selected monosaccharides, with their respective linkages and side chains when applicable, will automatically fill in the search bar and display matching results from our catalog.
- Monosaccharide :
- Glc
- GlcNAc
- Gal
- GalNAc
- Neu5Ac
- Fuc
- Neu5Gc
- Man
- Fru
- GulA
- ManA
- GalA
- Ara
- GlcA
- For polysaccharide searches, consult our list
-
Linkage :
- α1-2
- α1-3
- α1-4
- α1-5
- α1-6
- α2-3
- α2-6
- α2-8
- β1-2
- β1-3
- β1-4
- β1-6
- β2-1
- Side Chain :
- (
- )
- Functionalization
- Dual-functionalization
- Grafting on proteins
Functionalizations available for this glycan
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Lectins & labeled lectins by Origin (2 products)
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Bacterial lectins (2 products)
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- mail Customized functionalizations on request
Pseudomonas aeruginosa Lectin B (LecB) linked to biotin
Product code: LEC101-BT
Sugar specificity: Fucose (Fuc) ; Mannose (Man)
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Sugar specificity: Fucose (Fuc) ; Mannose (Man)
Additional specificity details: Methyl-α-fucose (αMeFuc) ; Lewis a
Structure: Homotetrameric lectin composed of four subunits of 11.7 kDa. One binding site per monomer which requires two calcium cations for binding.
Pseudomonas aeruginosa, is an opportunistic pathogen that produces two small soluble lectins, LecA and LecB, also named respectively PAI-L and PAII-L. PAII-L is a major virulence factor of P. aeruginosa and is toxic for respiratory epithelial cells. This lectin binds to many human and mammalian glycoproteins and plays a key role in adhesion to host cells . Invasion by P. aeruginosa can be inhibited by ligands of PAII-L. PAII-L is also involved in biofilm formation of P. aeruginosa and compounds interacting with this lectin were shown to inhibit biofilm formation. LecB agglutinates human and rabbit erythrocytes.
Synonyms:PAII-L ; LEC101-Bt
Laboratory reagent for research and development only. Not for human or animal use.
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Sugar specificity: Fucose (Fuc) ; Mannose (Man)