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Human & Bacterial Lectins

Our Lectin offer

Produced by bacterial fermentation

  • Ensuring repeatability and reliability of production and structure. heavy metals free, no glycosylated lectins.

  • This process allows any scale-up demand fitting your need.

High affinity for ligands

  • Very low Kd from micromolar range giving a better sensitivity to the ligand.

Fully Characterized, QA/QC policies

  • Monitoring by ITC (isothermal titration calorimetry) ensuring reliability of calculated Kd for a given lectin, affinity checking.

  • Tested on microarray developped by CFG (Consortium for Functional Glycomics). Product information is also available from CFG web Site.

  • Crystal structure is available for each lectin.

Calcium dependent

Calcium is required for the carbohydrate attachment which is an Asset for using these items as biotechnology tools for affinity chromatography.

Available with biotine or fluorophore labels on demand (FITC, Cy, Alexa…)

No alterations of binding properties despite presence of labeling.

Human & Bacterial Lectins

LecB (PA-IIL) from Pseudomonas aeruginosa linked to FITC- 1 mg

trait
LEC101-FITC

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Sugar specificity: Fucose
Sugar affinity: Kd for αMeFuc : 0.41 µM
Other known specificity Lewisa > αMeFuc > Fuc> Man
Human & Bacterial Lectins

LecB (PA-IIL) from Pseudomonas aeruginosa

LecB (PA-IIL) from Pseudomonas aeruginosa
trait
LEC101

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Sugar specificity: Fucose
Sugar affinity: Kd for αMeFuc : 0.41 µM
Other known specificity Lewisa > αMeFuc > Fuc> Man
Human & Bacterial Lectins

LecA (PA-IL) from Pseudomonas aeruginosa

LecA (PA-IL) from Pseudomonas aeruginosa
trait
LEC102

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Sugar specificity: αGalactose
Sugar affinity: Kd for αMeGal 50 µM
Other known specificity: αGal disaccharides > αMeGal > βMeGal
Human & Bacterial Lectins

RSL from Ralstonia solanacearum

RSL from Ralstonia solanacearum
trait
LEC202

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Sugar specificity: Fucose
Sugar affinity: Kd for αMeFuc 0.74 µM
Other known specificity: αFuc1-2Gal>αFuc1-6GlcNAC >αFuc1-4GlcNAC…
Human & Bacterial Lectins

BC2LA from Burkholderia cenocepacia

BC2LA from Burkholderia cenocepacia
trait
LEC301

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Sugar specificity: Mannose
Sugar affinity: Kd for αMeMan 2.75 µM
Other known specificity: All αMan-terminating oligosaccharides
Human & Bacterial Lectins

BC2LC-Nt from Burkholderia cenocepacia

BC2LC-Nt from Burkholderia cenocepacia
trait
LEC302

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Sugar specificity: Fucose
Sugar affinity: Kd for Lewisy 2.4 µM Kd for Fuc 2.7 mM
Other known specificity: Lewisy > H type 1 > Lewisa >...> Fuc
Human & Bacterial Lectins

DC-SIGN ECD (extra-cellular domain) 0.2 mg

DC-SIGN ECD (extra-cellular domain) 0.2 mg
trait
LEC401

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Sugar specificity: High Mannose
Known interactions: Various pathogen surface glycoconjugates (HIV, HCV, CMV, Ebola, Dengue,
M. tuberculosis...)
Other known specificity: Fuc, Lewisx, Lewisy
Human & Bacterial Lectins

Langerin ECD (extra-cellular domain) - 0.2 mg

Langerin ECD (extra-cellular domain) - 0.2 mg
trait
LEC402

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Sugar specificity: High Mannose
Known interaction: gp120 (HIV), Keratan sulfate
Other known specificity: Sulfated sugars (Sulfated Lewis x, sulfated galactose)