Hyaluronic acid oligosaccharides

Structural description

Hyaluronic Acid (HA) is a glycosaminoglycan built by sequence of β(1,3) glucuronic acid (GlcA) and β(1,4) N-acetylglucosamine (GlcNAc). HA is a major compound of the extracellular matrix to maintain tissue architecture, elasticity and hydration. However it also has other key functions including the regulation of cell behaviour through specific interactions with cell surface receptors and extracellular proteins.

Our oligosaccharides are manufactured by controlled endolyase scission of purified, low endotoxin Hyaluronic Acid (Streptococcal species). The oligosaccharides are obtained by high resolution gel filtration and purified on an analytical Superdex S75 HPLC column.

The oligosaccharides size range is from DP2 to DP 20 (DP = degree of polymerisation).

 

General formula: ∆HexAβ1,3 [GlcNAcβ1,4 GlcAβ1,3]n GlcNAc

With n = number of disaccharide units

∆HexA is the C4-C5 unsaturated hexuronic acid at the non-reducing end of the oligosaccharides produced by endolyase scission of the HA polymer.