Heparin oligosaccharides

Structural description

Manufactured from high grade porcine heparin using bacterial heparinase and purified by high resolution gel filtration.

General formula: ∆UA,2S-GlcNS,6S – (IdoA,2S – GlcNS,6S)n- IdoA,2S-GlcNS,6S

With n the number of disaccharide units
n = 0
in the dp4 (HO04) tetrasaccharide
n = 1
in the dp6 (HO06) hexasaccharide, etc.

The bacterial heparinase has an endolytic action and at the non-reducing end of the Oligosaccharides of uronic acid (∆UA).

Uronic acid (∆UA) at the non-reducing end of the oligosaccharides has a C4-C5 double bond as a result of the endolytic action of bacterial heparinase. Although the main disaccharide unit in these products is IdoA,2S – GlcNS,6S (approx 75%) saccharides in each size class show some variation in sulfation