Home puce Glycan Oligosaccharides puceGlobo-Series (P antigens)

Globo-Series (P antigens)

Globosides are major components of human erythrocytes and were termed like this since it was obtained as a globular precipitate. Glycosphingolipids (GLS’s) of the globo-series are membrane-associated antigens possessing as structural feature a Galα1-4Gal (galabiose-like) linkage which is responsible for their specific roles in recognition and cell differentiation. They are recognized by proteins of pathogenic E. coli in human epithelial cells of the urinary tract. They are also receptors for Shiga toxin and verotoxin (Shiga-like toxin) and constitute the basis of the P-blood group system. Many of them have been described as tumor-associated antigens.


Stage-Specific Embryonic Antigens (SSEA-3 & SSEA-4)

Globopentaose (Gb5)-N-Acetyl-spacer 3-Biotin

Globopentaose (Gb5)-N-Acetyl-spacer 3-Biotin
trait
GLY122-NAc-sp3-Bt

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Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-N-Acetyl-Spacer3-biotin
P Blood group antigens & Analogues

Globotetraose-Nac-sp3-biotin

Globotetraose-Nac-sp3-biotin
trait
GLY121-NAc-sp3-Bt

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GalNAcβ1-3Galα1-4Galβ1-4Glc-Nac-spacer3-Biotin
Stage-Specific Embryonic Antigens (SSEA-3 & SSEA-4)

Globopentaose (Gb5)-N-Acetyl-Propargyl

Globopentaose (Gb5)-N-Acetyl-Propargyl
trait
GLY122-NPR

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Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-N-Acetyl-Propargyl
Forssman antigens

Forssman antigen pentaose linked to BSA

Forssman antigen pentaose linked to BSA
trait
GLY132-BSA

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GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
P Blood group antigens & Analogues

Globotriaose / Gb3 / Pk antigen

Globotriaose / Gb3 / P<sup>k</sup> antigen
trait
GLY120

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Galα1-4Galβ1-4Glc
C18H32O16
FW 504.43
[66580-68-5]
P Blood group antigens & Analogues

Globotetraose / Gb4 / P antigen

Globotetraose / Gb4 / P antigen
trait
GLY121

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GalNAcβ1-3Galα1-4Galβ1-4Glc
C26H45NO21
FW 707.62
[75660-79-6]
Stage-Specific Embryonic Antigens (SSEA-3 & SSEA-4)

Globopentaose (Gb5) / Stage Specific Embryonic Antigen 3a / SSEA-3a

Globopentaose (Gb5) / Stage Specific Embryonic Antigen 3a / SSEA-3a
trait
GLY122

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Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
C32H55NO26
FW 869.76
[71937-76-3]
Globo-Series (core structure type 4)

Globo-A heptaose

Globo-A  heptaose
trait
GLY124

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GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Galα1-4
Galβ1-4Glc
C46H78N2O35
FW 1219.09
Globo-Series (core structure type 4)

Globo-B heptaose

Globo-B  heptaose
trait
GLY125

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Galα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Galα1-4
Galβ1-4Glc
C44H75NO35
FW 1178.04
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