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Ganglio-Series

Gangliosides are complex glycosphingolipids (abbreviated GSL and also called glycolipids) that contain a sialic acid. They are buildings blocks of cell membrane of vertebrates and play key roles in cell to cell and cell to extracellular matrix communication (Receptors for toxin, hormone, virus…). As part of tumor pathogenesis, these molecules are proposed as vaccine targets.

Further reading: For more information please refer to our Tumor-associated carbohydrate antigens (TACA) brochure

Ganglioside sugar Nomenclature:

  • G stands for Ganglioside
  • M, D, T & Q stands for mono, di, tri, quadri number of sialic acids
  • 1, 2, 3 as the order of distance migration in thin layer chromatography

Modified from Essentials of Glycobiology 2nd Edition;Varki A, Cummings RD, Esko JD, et al., editors. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009

Ganglio-Series

aGM2 Ganglioside sugar-N-Acetyl-propargyl

aGM2  Ganglioside sugar-N-Acetyl-propargyl
trait
GLY104-NPR

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GalNAcβ1-4Galβ1-4Glc-NAc-propargyl
Ganglio-Series

aGM2 / Ganglioside sugar / asialo GM2 / GA2

aGM2 / Ganglioside sugar / asialo GM2 / GA2
trait
GLY104

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GalNAcβ1-4Galβ1-4Glc
C20H35NO16
FW 545.48
Ganglio-Series

Fucosyl GM1 Ganglioside sugar

Fucosyl GM1 Ganglioside sugar
trait
GLY103

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Fucα1-2Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
C43H71N2O33Na
FW 1168.00
Ganglio-Series

aGM1 / Ganglioside sugar asialo GM1 / GA1

aGM1 / Ganglioside sugar  asialo GM1  / GA1
trait
GLY102

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Galβ1-3GalNAcβ1-4Galβ1-4Glc
C26H45NO21
FW 707.62
[75645-24-8]
Ganglio-Series

GT1c Ganglioside sugar

GT1c Ganglioside sugar
trait
GLY101

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Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-8
Neu5Acα2-3)Galβ1-4Glc
C59H93N4O45Na3
FW 1647.33
Ganglio-Series

GT1a Ganglioside sugar

GT1a Ganglioside sugar
trait
GLY100

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Neu5Acα2-8Neu5Acα2-3Galβ1-3GalNAcβ1-4
(Neu5Acα2-3)Galβ1-4Glc
C59H93N4O45Na3
FW 1647.33
Ganglio-Series

GD1b Ganglioside sugar

GD1b Ganglioside sugar
trait
GLY099

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Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)
Galβ1-4Glc
C48H77N3O37Na2
FW 1334.09
Ganglio-Series

GD1a Ganglioside sugar

GD1a Ganglioside sugar
trait
GLY098

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Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)
Galβ1-4Glc
C48H77N3O37Na2
FW 1334.09
Ganglio-Series

GM1b Ganglioside sugar

GM1b Ganglioside sugar
trait
GLY097

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Neu5Acα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glc
C37H61N2O29Na
FW 1020.86
Ganglio-Series

GM1a Ganglioside sugar

GM1a Ganglioside sugar
trait
GLY096

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Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
C37H61N2O29Na
FW 1020.86
Ganglio-Series

GT2 Ganglioside sugar

GT2 Ganglioside sugar
trait
GLY095

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GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-8Neu5Acα2-3)
Galβ1-4Glc
C53H83N4O40Na3
FW 1485.19
Ganglio-Series

GD2 Ganglioside sugar

GD2 Ganglioside sugar
trait
GLY094

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GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc
C42H67N3O32Na2
FW 1171.95
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